Publikációk - Innovatív Gyógyszeripari és Kirotechnológiai Kutatócsoport

2026

Rávai B., Ujj D.V., Orosz M.J., Revenco E., Béni Sz., Tajti Á., Bálint E.

Pilot-Scale Continuous Flow Synthesis of Capsaicinoids and Their Formulation with Cyclodextrins

ACS Omega, 11(3), 4570–4580

Samra A., Radoua A., Sila Tanaydin E., Alrustom B., Bordessoules M., Fischer T., Callot M., Georgsson S., Rávai B., Mátravölgyi B. et al.

Quantifying loss of cell viability or adhesion using methylene blue

Methods in Cell Biology, 206, 125–143

DOI: 10.1016/bs.mcb.2026.02.015 →

Gerő V., Steinsits D., Tamás Szabó P., Bálint E.

Flow Chemistry Meets Green Solvents: Telescoped Synthesis of Triazolyl Phosphoramidates and Phosphinamides in γ-Valerolactone

ChemSusChem, 19(9), e70680

DOI: 10.1002/cssc.70680 →

Ujj D.V., Kasal P., Fejős I., Béni Sz., Kardos J., Benkovics G., Bálint E., Mátravölgyi B.

Complexation of Citalopram with β-Cyclodextrin, Mono-Subetadex and Subetadex

ACS Omega, 11(16), 24323–24333

DOI: 10.1021/acsomega.5c13544 →

Gyöngyössy Á., Orosz J.M., Pusztai É., Pomberger A., Wigh D., Bálint E.

Flow synthesis of heterocyclic capsaicinoid analogues supported by complementary DoE and Bayesian optimization

Chemical Engineering Science (2026)

DOI: 10.26434/chemrxiv.15001104/v1 →

2025

Mika L.T., Árvai Cs., Bálint E., Rávai B.

Evaluating Greenness of Solvents

Encyclopedia of Green Chemistry, Vol. 3, pp. 1–16, Elsevier

DOI: 10.1016/B978-0-443-15742-4.00051-X →

Rávai B., Németh Á.S., Kelemen Zs., Bálint E.

Microwave-Assisted Multicomponent Synthesis of Spirooxindole Dihydropyridine Bisphosphonates

European Journal of Organic Chemistry, 28(6), e202400873

DOI: 10.1002/ejoc.202400873 →

Rávai B., Kese I., Szakály P.S., Herr D., Iványi R., Bálint E., Szőcs L.

Mono-(6-sulfinic acid)-Sugammadex: A newly identified cyclodextrin-based oxidative impurity in industrial production

Carbohydrate Polymers, 362, 123659

DOI: 10.1016/j.carbpol.2025.123659 →

Steinsits D., Rávai B., Kelemen Zs., Hackler L., Vernyik V., Puskás L.G., Bálint E.

3,3-Bis(hydroxyaryl)oxindoles and Spirooxindoles Bearing a Xanthene Moiety

Journal of Organic Chemistry, 90(19), 6454–6467

DOI: 10.1021/acs.joc.5c00270 →

Nguyen H.H.T., Bálint E., Mátravölgyi B.

Time‐Dependent Resolution of an Atropisomeric 1‐Arylpyrrole by a Novel 1‐Arylethylamine Saltforming Agent

Chirality, 37(10), e70054

DOI: 10.1002/chir.70054 →

Rávai B., Orosz J.M., Steinsits D., Bálint E.

A BME Innovatív Gyógyszeripari és Kirotechnológiai Kutatócsoport áramlásos kémia területén végzett kutatásai

Magyar Kémiai Folyóirat, 131(2–4), 200–209

DOI: 10.24100/MKF.2025.02-04.200 →

2024

Rávai B., Popovics-Tóth N., Komka K., Csontos I., Szokol B., Őrfi Z., Őrfi L., Bálint E.

Phosphoryl- or phosphinoyl-functionalized benzo[de]isoquinolinones

Reaction Chemistry & Engineering, 9(3), 583–593

DOI: 10.1039/D3RE00489A →

Rávai B., Orosz M.J., Péterfi O., Galata D.L., Bálint E.

Flow chemical laboratory practice for undergraduate students: synthesis of paracetamol

Journal of Flow Chemistry, 14(2), 409–415

DOI: 10.1007/s41981-023-00303-y →

Orosz M.J., Rávai B., Mátravölgyi B., Bálint E.

Flow Synthesis of Capsaicin and Capsaicinoid Analogues

ACS Sustainable Chemistry & Engineering, 12(20), 7913–7923

DOI: 10.1021/acssuschemeng.4c01839 →

Szabó K., Kelemen Zs., Szabó P.T., Bálint E.

Synthetic and mechanistic studies of the multicomponent reaction

Reaction Chemistry & Engineering, 9(12), 3222–3230

DOI: 10.1039/D4RE00387J →

2023

Popovics-Tóth N., Bao T.D.T., Tajti Á., Mátravölgyi B., Kelemen Zs., Perdih F., Hackler L., Puskás L.G., Bálint E.

Three-Component Reaction of 3-Formyl-6-Methylchromone, Primary Amines, and Secondary Phosphine Oxides

ACS Omega, 8(2), 2698–2711

DOI: 10.1021/acsomega.2c07333 →

Orosz J.M., Ujj D., Kasal P., Benkovics G., Bálint E.

Continuous flow synthesis of 6-monoamino-6-monodeoxy-β-cyclodextrin

Beilstein Journal of Organic Chemistry, 19, 294–302

DOI: 10.3762/bjoc.19.25 →

2022

Rávai B., Popovics-Tóth N., Tajti Á., Bálint E.

Synthesis of isoindolinone phosphonates and their related derivatives by multicomponent reaction

Phosphorus Sulfur and Silicon and the Related Elements, 197(5–6), 599–600

DOI: 10.1080/10426507.2021.2012179 →

Popovics-Tóth N., Tajti Á., Bálint E.

Biginelli reaction of β-ketophosphonates, aromatic or aliphatic aldehydes and urea derivatives

Phosphorus Sulfur and Silicon and the Related Elements, 197(5–6), 597–598

DOI: 10.1080/10426507.2021.2011880 →

Popovics-Tóth N., Turpanova M., Németh K., Hackler Jr. L., Puskás L.G., Bálint E.

Synthesis of arylphosphinoyl-functionalized dihydroisoquinolines by Reissert‑type reaction

Tetrahedron, 111, 132720

DOI: 10.1016/j.tet.2022.132720 →

Popovics-Tóth N., Bálint E.

Multicomponent Synthesis of Potentially Biologically Active Heterocycles Containing a Phosphonate or a Phosphine Oxide Moiety

Acta Chimica Slovenica, 69, 735–755

DOI: 10.17344/acsi.2022.7648 →

Szabó K.E., Akali R., Tajti Á., Popovics-Tóth N., Bálint E.

Microwave-assisted synthesis of α-aminophosphonate-chromone hybrids using Kabachnik-Fields Reaction

Arkivoc, 3, 256–271

DOI: 10.24820/ark.5550190.p011.887 →

Popovics-Tóth N., Tajti Á., Hümpfner E., Bálint E.

Synthesis of 3,4-Dihydropyrimidin-2(1H)-one-phosphonates by the Microwave-Assisted Biginelli Reaction

Catalysts, 11(1), 45

DOI: 10.3390/catal11010045 →

2021

Bálint E., Popovics-Tóth N., Tajti Á., Rávai B., Szabó K.E., Perdih F.

Microwave-Assisted Multicomponent Syntheses of Heterocyclic Phosphonates

Chemistry Proceedings, 3(1), 108

DOI: 10.3390/ecsoc-24-08548 →

Tajti Á., Szabó K.E., Popovics-Tóth N., Iskanderov J., Perdih F., Hackler L., Kari B., Puskás L.G., Bálint E.

PMDTA-catalyzed multicomponent synthesis and biological activity of 2-amino-4H-chromenes containing a phosphonate or phosphine oxide moiety

Organic & Biomolecular Chemistry, 19, 6883–6891

DOI: 10.1039/D1OB01204E →

Popovics-Tóth N., Rávai B., Tajti Á., Varga B., Bagi P., Perdih F., Szabó P.T., Hackler L., Puskás L.G., Bálint E.

Three-component synthesis, utilization and biological activity of phosphinoyl-functionalized isoindolinones

Organic & Biomolecular Chemistry, 19(40), 8754–8760

DOI: 10.1039/d1ob01610e →

Popovics-Tóth N., Szabó K.E., Bálint E.

Study of the Three-Component Reactions of 2-Alkynylbenzaldehydes, Aniline, and Dialkyl Phosphites

Materials, 14(20), 6015

DOI: 10.3390/ma14206015 →

Tajti Á., Kovács B.D., Popovics-Tóth N., Perdih F., Bálint E.

Microwave-assisted synthesis of benzo[b]phosphole oxide derivatives by oxidative addition of acetylenes

Tetrahedron, 102, 132527

DOI: 10.1016/j.tet.2021.132527 →

Tripolszky A., Tóth E., Szabó P.T., Hackler L., Kari B., Puskás L.G., Bálint E.

Synthesis and In Vitro Cytotoxicity and Antibacterial Activity of Novel 1,2,3-Triazol-5-yl-Phosphonates

Molecules, 25(11), 2643

DOI: 10.3390/molecules25112643 →

Tajti Á., Tóth N., Rávai B., Csontos I., Szabó P.T., Bálint E.

Study on the Microwave-Assisted Batch and Continuous Flow Synthesis of N-Alkyl-Isoindolin-1-One-3-Phosphonates

Molecules, 25(14), 3307

DOI: 10.3390/molecules25143307 →

2018

Mátravölgyi B., Hergert T., Bálint E., Bagi P., Faigl F.

Access to Fluorazones by Intramolecular Dehydrative Cyclization of Aromatic Tertiary Amides

Journal of Organic Chemistry, 83(4), 2282–2292

DOI: 10.1021/acs.joc.7b03176 →

Bálint E., Tajti Á., Tripolszky A.

Synthesis of α-aminophosphonates by the Kabachnik–Fields reaction and by the Pudovik reaction

Organophosphorus Chemistry: Novel Developments, pp. 108–147, De Gruyter

DOI: 10.1515/9783110535839-006 →

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